Preimplantation genetic testing is used to screen for a broad range of abnormalities (PGS or preimplantation genetic screening) or identify specific genetic or chromosomal problems (PGD or preimplantation genetic diagnosis). Many people use PGD to refer to either process. PGD can diagnose a number of disorders, preventing birth defects, miscarriage, and genetic disease. Not all women may beneift from PGD testing; those at a high risk of miscarriage or genetic problems should consider having the procedure done.

How PGD Testing Works

During PGD, embryos can be biopsied at several points during their development. However, biopsy at the blastocyst stage, also known as a trophoblast biopsy, is currently the preferred time for biopsy. Embryos that fail to reach the blastocyst stage or which appear to be fragmented or degenerated under the microscope are not biopsied since they are already considered nonviable.PGD can identify specific gene mutations, such as the gene for cystic fibrosis. The test can also identify chromosomal translocations, which can cause miscarriage and birth defects. PGD is safe for the embryo, and helps ensure that only embryos that appear to be genetically normal are transferred.

‍When to Consider PGD

If you or your partner have a family history of a serious genetic illness like cystic fibrosis or sickle cell anemia, going through PGD can prevent you from passing that illness on to your child. PGD testing has the power to prevent certain genetic diseases, and it gives couples the confidence to have children with a lower level of disease risk.You should also consider PGD if you have a history of unexplained miscarriage. PGD can identify chromosomal abnormalities known as translocations, which sometimes contribute to miscarriage. Typically, the procedure is recommended for women who have had more than 3 miscarriages that do not have another known cause.

‍Limitations of PGD

‍Although PGD testing is valuable, it also has limitations. It is not possible to screen for all genetic illnesses, and some illnesses are linked to multiple genes or genes that have not yet been identified. In addition, some miscarriages or birth defects are caused by other problems. However, in women who have a history of genetic illness or miscarriage, PGD can be a valuable tool for increasing the chances of a live, healthy birth. If you are interested in treatment for your infertility, Dr. Randy Morris would be happy to meet with you. To schedule a consultation today, please click below and enter your information or call IVF1 at (630) 357-6540.