Specialized testing for chromosomal structural rearrangements.

What is PGT-SR?

PGT-SR, or preimplantation genetic testing for structural rearrangements, is a specialized type of genetic testing used in the field of reproductive medicine. It's designed for individuals or couples who are known carriers of chromosomal structural rearrangements, such as translocations or inversions. These structural changes in chromosomes can lead to fertility issues, recurrent miscarriages, or the birth of a child with a genetic disorder. In PGT-SR, embryos created through in vitro fertilization (IVF) are tested for these specific chromosomal rearrangements before being transferred to the uterus.

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What is a Translocation?

A translocation is a type of abnormality in the structure of a chromosome. There are two main types of translocations: reciprocal (also known as non-Robertsonian) and Robertsonian. Reciprocal translocation is the more common type. In a reciprocal translocation, a small portion of two separate chromosomes have “swapped” positions with each other.

Detecting Translocations with PGT-SR

Couples in which one partner has a translocation usually have a history of recurrent miscarriage. During the evaluation, a chromosome analysis on both partners identifies the translocation abnormality.

At this point, their options are to continue to try to conceive naturally, use a donor (egg or sperm depending on which partner is the carrier), or use PGT-SR. If they decide to try PGT-SR, blood is obtained from the affected partner so that the translocation can be characterized.

Specific fluorescent probes are used that recognize and attach to an entire chromosome. For example, a translocation between chromosomes #4 and #11 would require whole chromosome probes for each of those chromosomes. Each probe would have a different color for easy identification. After an embryo is obtained from IVF, the polar body or blastomere (or sometimes both) are removed from the embryo. These biopsied cells must be at a certain stage in order for the process to work, so they are converted in the lab. The probe is then applied and read. A normal chromosome would appear with a single color. A chromosome with a translocation will show two colors.

In this way, embryos can be identified that do not have translocations and can then be transferred to the uterus.

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Patient Testimonials

I honestly can’t praise this company enough. Dr. Randy Morris bedside manner is absolutely amazing, his staff professionalism and customer service is also amazing. Your experience with this company will be nothing but perfect. From the initial call to the receptionist. To speaking with the nursing staff, billing, etc. everyone wants to help you with family planning. No matter what my outcome is, I know I’m with a co that will make sure I have the best chances. Thank you to Dr Randy Morris and Staff a bunch!

Misty Johnson

I don't even know where to start...THANK YOU! Thank you for giving us our son. We went through a year of IVF. Although there may have been things I didn't want to hear (chances of pregnancy, factors out of our control, etc.) it was important to hear the truth and know what our chances were. The staff was always great with us and they were very patient. They really have everything figured out and what the best options out for outcomes. I never felt pressured to make certain decisions and always felt well informed. Again, I can't thank Dr. Morris and all his staff for everything!!!

Lauren Throm

He is a very professional and good doctor. the whole clinic is very nice. all the staff are amazing. The doctor operated on me for endometriosis and I got pregnant during the second IVF. we have a wonderful 1 year old son. thank you doctor we still have an embryo, I think I will definitely come back to you in a year or two.

Ziva Ru

Dr. Morris is by far the best fertility doctor! When I transferred to IVF1 from my previous fertility doctor, he read all my medical records in depth. Never once did I feel stressed or unsure of what was happening. The entire staff there is so nice and make you feel so comfortable. It was so easy to schedule appointments, get medications, or ask a nurse a question. My calls were always returned within 20 minutes. I highly recommend IVF1! Dr. Morris made it possible for us to get pregnant!


I’m so grateful to have been referred to Dr. Morris and his team! I’ve spent the last month or so working with the team and they’ve made what is naturally a hard process both mentally and physically as comforting and easy as possible. Dr. Morris’s success rates speak for themselves, but what I want to let everyone know is that he is equally comforting. A special thank you to Jocelyne, Pam and Barbie, these three women on his staff from front desks to RNs really have made the experience an extremely positive one. PS. My cousin who referred me to Dr. Morris has a smart, healthy and beautiful baby boy who he helped bring into this world!

Alex Villa

Amazing staff. They made us feel like family. They cried when I called to tell them the birth of our daughter. Starting round two next month. Simply the best. They care!

BT Warner

The staff is amazing here. I’m in the middle of IVF and had an issue with a medication and they went above and beyond to make sure everything was done to continue our journey (on the weekend no less); truly above and beyond. The staff are very caring and professional. Definitely recommend Dr. Morris and this amazing practice.

Megan Buetikofer

Dr. Morris and staff were very friendly. Dr. Morris was very informative and patient with answering all questions I had. We were uncertain on the options and next steps to take and Dr. Morris explained all the details and options we have. Excellent staff and a great doc.

Jenita Crawford

Thanks to Dr.Morris I am holding today my little dream girl. I don't have enough words to express how thankful I am to him and everyone working in IVF1 Naperville. Highly recomend Dr.Morris and his clinic to everyone looking for real professional help and attitude!

Petya Vasilev
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