What is Preimplantation Genetic Testing?

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Preimplantation Genetic Testing (PGT)

Recently, the Society for Assisted Reproductive Technologies (SART) and the American Society for Reproductive Medicine (ASRM) have changed the recommended terms used to describe the testing of embryos:

A general term which describes the removal of cells from an egg or embryo and subsequent testing. It is subdivided into a few different types:

  • PGT-A: The A stands for aneuploidy. Aneuploid embryos do not have the correct number of chromosomes.
  • PGT-M: The M stands for monogenic, meaning one gene. This is most commonly used when the parents are carriers for a genetic mutation. Testing is done to reduce the chances of a genetic disease in the fetus.
  • PGT-SR: The SR stands for structural rearrangement. Occasionally, parents may have abnormalities in the structure of a chromosome, known as a translocation. Translocations can lead to recurrent miscarriages.
  • Preimplantation genetic diagnosis: This term was used initially to describe any type of embryo testing. Many people still use this term instead of PGT to refer to any type of embryo testing.
  • Preimplantation screening: This was an older method to refer to aneuploidy screening, now referred to as PGT-A.
  • Comprehensive chromosome screening: This term was used in the past when technology allowed the screening of all chromosomes instead of just a smaller number.

About Preimplantation Genetic Testing

Preimplantation genetic testing (PGT) represents a cutting-edge frontier in reproductive medicine, offering prospective parents a way to understand the genetic health of embryos before pregnancy. This advanced procedure is conducted during in vitro fertilization (IVF), where embryos are tested for specific genetic conditions or chromosomal normalcy before being transferred to the uterus.

PGT can be a valuable tool for couples with a history of genetic disorders, recurrent miscarriages, or unsuccessful IVF cycles. It also offers older parents-to-be a higher chance of a healthy pregnancy. However, it's important to discuss the benefits, limitations, and ethical considerations with a fertility specialist. While PGT can increase the likelihood of a successful pregnancy, it does not guarantee it, and not all genetic conditions can be detected. This comprehensive approach aims to enhance the chances of a healthy pregnancy, guiding parents through a journey filled with informed choices and personalized care.

Types of Preimplantation Genetic Testing

Preimplantation Genetic Testing Methods

Once genetic material has been obtained from an embryo there are a number of possible tests that can be performed for the identification of different types of problems.

PGT-A for determination of chromosome number: Also known as aneuploidy testing.

‍PGT-M for genetic mutations: Many medical problems caused by gene mutations can be identified. This type of testing can also help eliminate cancer from a family.

PGT-SR for structural chromosome abnormalities: Includes testing for translocations, a common cause for miscarriage

PGT-HLA for tissue typing: Revolutionary method for finding transplant matches for sick and dying children.

‍PGT for Sex Selection: The most accurate and successful method for selecting the sex of a baby -- often referred to as gender selection.‍

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I don't even know where to start...THANK YOU! Thank you for giving us our son. We went through a year of IVF. Although there may have been things I didn't want to hear (chances of pregnancy, factors out of our control, etc.) it was important to hear the truth and know what our chances were. The staff was always great with us and they were very patient. They really have everything figured out and what the best options out for outcomes. I never felt pressured to make certain decisions and always felt well informed. Again, I can't thank Dr. Morris and all his staff for everything!!!

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The staff is amazing here. I’m in the middle of IVF and had an issue with a medication and they went above and beyond to make sure everything was done to continue our journey (on the weekend no less); truly above and beyond. The staff are very caring and professional. Definitely recommend Dr. Morris and this amazing practice.

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Dr. Morris is by far the best fertility doctor! When I transferred to IVF1 from my previous fertility doctor, he read all my medical records in depth. Never once did I feel stressed or unsure of what was happening. The entire staff there is so nice and make you feel so comfortable. It was so easy to schedule appointments, get medications, or ask a nurse a question. My calls were always returned within 20 minutes. I highly recommend IVF1! Dr. Morris made it possible for us to get pregnant!

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He is a very professional and good doctor. the whole clinic is very nice. all the staff are amazing. The doctor operated on me for endometriosis and I got pregnant during the second IVF. we have a wonderful 1 year old son. thank you doctor we still have an embryo, I think I will definitely come back to you in a year or two.

Ziva Ru

I’m so grateful to have been referred to Dr. Morris and his team! I’ve spent the last month or so working with the team and they’ve made what is naturally a hard process both mentally and physically as comforting and easy as possible. Dr. Morris’s success rates speak for themselves, but what I want to let everyone know is that he is equally comforting. A special thank you to Jocelyne, Pam and Barbie, these three women on his staff from front desks to RNs really have made the experience an extremely positive one. PS. My cousin who referred me to Dr. Morris has a smart, healthy and beautiful baby boy who he helped bring into this world!

Alex Villa

Thanks to Dr.Morris I am holding today my little dream girl. I don't have enough words to express how thankful I am to him and everyone working in IVF1 Naperville. Highly recomend Dr.Morris and his clinic to everyone looking for real professional help and attitude!

Petya Vasilev

Dr. Morris and staff were very friendly. Dr. Morris was very informative and patient with answering all questions I had. We were uncertain on the options and next steps to take and Dr. Morris explained all the details and options we have. Excellent staff and a great doc.

Jenita Crawford

I honestly can’t praise this company enough. Dr. Randy Morris bedside manner is absolutely amazing, his staff professionalism and customer service is also amazing. Your experience with this company will be nothing but perfect. From the initial call to the receptionist. To speaking with the nursing staff, billing, etc. everyone wants to help you with family planning. No matter what my outcome is, I know I’m with a co that will make sure I have the best chances. Thank you to Dr Randy Morris and Staff a bunch!

Misty Johnson
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