Clomid is a first-line oral medication used to promote ovulation in women. Femara is a more recent drug that also promotes ovulation, but may be more effective in women who have not responded to Clomid and in women who have PCOS. Below, we will take a look at Femara vs. Clomid.
Femara, generically known as letrozole, has relatively recently been used for infertility, although it has been used in the treatment of breast cancer for years. Femara is used to induce ovulation in women who do not ovulate regularly on their own, and to boost the chances of pregnancy in women who are already ovulating.
Femara is classified as an aromatase inhibitor. It blocks the action of aromatase, an enzyme that is involved in the production of estrogen in the body. As a result, the pituitary gland produces more follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are involved in the maturation of eggs and in the production of estrogen.
Clomid is an oral medication that has often been used as the first line of treatment for infertility. Clomid works by blocking estrogen receptors in the body. Although the mechanism of action is different than with Femara, the result is still an increase in FSH and LH production by the pituitary gland.
Femara vs. Clomid
Clomid is effective at bringing about ovulation in a large number of women, and is often the first treatment prescribed for infertility. However, Clomid stays in the body for a long time, and has the potential to have a negative impact on the uterine lining and cervical mucous. Femara is frequently used as the second drug in women who have not responded to Clomid, but are not ready to progress to injectable gonadotropins.
Femara may be especially appropriate for women who have polycystic ovarian syndrome (PCOS). Women with PCOS are less likely to ovulate and less likely to get pregnant with Clomid than the general population, but a well done study found that Femara may be more effective for this population.
Both Femara and Clomid are widely considered to be safe drugs, although there is a small amount of risk associated with the use of any medication.
Only a doctor can tell you which course of treatment is right for your infertility. Dr. Randy Morris would be happy to meet with you about treatment for your infertility. To schedule your consultation today, please click below and enter your information or call IVF1 at (630) 357-6540.