An infertility doctor from Ireland presented research at the 25th annual conference of the European Society of Human Reproduction and Embryology in July 2009 that appears to show that IVF success may partly depend on genetic factors. […]
Daily sex (or ejaculating daily) for seven days improves men’s sperm quality by reducing the amount of DNA damage, according to an Australian study presented recently to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam. This study made headlines around the world. However, there is still no evidence that frequent ejaculation will improve the actual chances to have a baby. […]
A study was done in 2009 to determine whether a policy of elective single-embryo transfer (e-SET) in IVF lowers the rate of multiple births (twins, etc.) without compromising the live birth rate. Elective single-embryo transfer (e-SET) is the transfer of one embryo into the uterus during IVF as compared to two.
Yury Verlinsky (09/01/1943- 07/16/2009)
We regret to announce the death on 16th July, 2009 after a period of illness of Dr. Yury Verlinsky, Aged 66.
Dr. Yury Verlinsky, born September 1, 1943, in Siberia, graduated and obtained his PhD in Cytogenetics and Embryologyfrom Kharkov University. He started his research career in genetics in Ukraine already in […]
Many questions are asked about the freezing of embryos and its effect on pregnancy rates. How long do frozen embryos stay viable? Is there a lesser chance of pregnancy down the road? What effect will freezing embryos have on the fetus? Numerous studies have been performed that prove embryo freezing is safe and effective. The embryos are viable for long periods of time and have produced many successful pregnancies. In fact, a recent study reported at the European Society for Human Reproduction and Embryology discovered that children born from frozen embryos do better and have a higher birth weight than children born from a fresh transfer. […]
For the last 10 years, the techniques of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) have been used to detect genetic mutations and chromosomal abnormalities in developing embryos. It has been a revolutionary method that has resulted in reductions in the rate of miscarriage and babies with chromosome abnormalities and has accurately identified hundreds of different genetic disorders in the embryos of IVF patients.
As women age, the probability for chromosomal abnormalities increases. PGS involves removing a cell or two from the early stages of a growing embryo and analyzing the number of chromosomes. Normal human embryos contain 23 pairs of chromosomes. Commonly however, embryos will contain too many or too few chromosomes. These abnormalities which are known as aneuploidies, can lead to implantation failure, miscarriage or birth defects such as Down’s syndrome.
PGD involves removing cells from the early embryo to test for genetic mutations which can cause disease.
Normal thyroid hormone production is though to be important for reproduction. A slightly underactive thyroid gland does not affect the success of IVF according to a recent study that was presented at the annual meeting of the American Society for Reproductive Medicine in 2007.
A common question asked by patients who plan to freeze embryos from their IVF treatment is, “How long do frozen embryos remain viable?”. There have been several reports of embryos frozen for many years that still produced a pregnancy.
In the medical literature, the longest reported time for an embryo to be frozen, thawed and result in a viable healthy delivery was twelve years.
This is of special importance since some countries have passed legislation requiring embryos to be destroyed if not used after two to five years.
Miscarriages after infertility treatment are common. Numerous studies have shown that most of miscarriages are due to abnormalities in the number of chromosomes in the embryo. This is called aneuploidy. Normally, an embryo should have 46 chromosomes or, more precisely – 23 pairs of chromosomes. In two-thirds to three fourths of all miscarriages, the embryo has something other than 46 chromosomes. In addition, it seems that certain chromosomes are present in abnormal numbers more frequently. a recent study found that eight chromosomes (X, Y, 13, 15, 16, 18, 21, and 22) accounted for 83% of the abnormalities found in miscarriage specimens. […]
Several studies have previously looked at whether use of low dose aspirin during in vitro fertilization cycles would result in a higher chance for implantation. Some of these studies have shown an improvement in implantation rates, some have not. […]
A recent study suggests that preimplantation genetic diagnosis – PGD may be ineffective as a means for increasing the live birth rate in older women with infertility and, in fact, may actually decrease the live birth rate. […]
PGD reveals cause for IVF implantation failure During in vitro fertilization – IVF, embryos are chosen for transfer based on two separate criteria. In all IVF cycles, the microscopic evaluation of the embryo is carried out at varied stages to identify those with the best overall appearance and development characteristics. In some IVF cycles, preimplantation genetic diagnosis – PGD is performed to also identify those embryos with abnormalities in the number of chromosomes present. These abnormalities are known as aneuploidies. Embryo chromosome abnormalities such as aneuploidies are thought to be responsible for implantation failure, miscarriage and birth defects. […]
This article will be of interest to couples that are being treated with IVF or have had multiple IVF failures.
Every fertility doctor has heard this at one time or another. During an embryo transfer, the patient will ask, “Can you put some glue in their so the embryo will stick?”
Despite the numerous advances that have been made in human in vitro fertilization, several as yet undetermined factors appear to contribute to embryo implantation.
In an attempt to optimize the growth conditions of embryos in the laboratory, a number of different additives have been investigated. Commonly, embryologists will add proteins the culture media to provide a source of energy for embryo development and also to act as a “reservoir” for various necessary vitamins and minerals. The most commonly used protein used is called albumin. […]
ACOG Opposes Sex Selection for Family Planning Purposes Washington, DC — Helping patients to choose the sex of their offspring to avoid serious sex-linked genetic disorders is considered ethical for doctors, but participating in sex selection for personal and family reasons, such as family balancing, is not, according to an opinion issued today by the Committee on Ethics of The American College of Obstetricians and Gynecologists (ACOG). The Committee concludes that the ethical objection to sex selection based solely on family balancing or personal preference holds, regardless of the timing of the selection (ie, preconception or postconception) or the stage of development of the embryo or fetus, because such requests may ultimately support sexist practices. […]
This article will be of interest to women with ovarian cysts due to endometriosis or other causes and who are considering treatment with in vitro fertilization – IVF. A recent study presented at the annual meeting of the American Association of Gynecologic Laparoscopists, compared IVF patients who first underwent surgery to remove ovarian cysts to those who left the cysts intact. […]
This article will be of interest to older women who are interested in attempting pregnancy using donor eggs. 67 year old woman pregnant from egg donationRecently, it was widely reported that a 67-year-old woman, Carmela Bousada, lied to a U.S. fertility clinic (not ours) — saying she was 55 — in order to receive treatment with egg donation. The pregnancy and delivery was a twin pregnancy. Previously, a Romanian citizen named Adriana Iliescu gave birth to a singleton baby in January 2005, also at the age of 66. Bousada was 130 days older than Iliescu when they each gave birth. […]
This study will be of interest to couples that are being treated for infertility with
in vitro fertilization – IVF
. Specifically those who are having embryo transfer on day 3 and who are considering the technique known as assisted hatching.
A recent study suggested that success rate of IVF may be reduced by over one half by the presence of infection with the virus, HPV. HPV infection may be an indicator of IVF failure. […]
Metformin ineffective for IVF
Metformin (Glucophage) is a commonly used treatment for polycystic ovary syndrome (PCOS) . Metformin is used to treat insulin resistance which is commonly found in women with PCOS. There is sufficient data currently to state that metformin use in PCOS patients can result in ovulation and thus increased fertility in PCOS patients. […]
Egg donation requires an egg donor to take injectable fertility medications and have her eggs removed (egg retrieval). Is this a risk to her fertility? […]