|Minimal Stimulation IVF|
Minimal stimulation IVF
For many years there has been interest in minimal stimulation IVF. Recent reports in the popular media have made minimal stimulation IVF a topic of interest to infertile couples. IVF stimulation protocols can be divided into three broad groups:
Minimal stimulation IVF with Clomid is less effective than standard in vitro fertilizationClomid is an oral medication that has been used for over forty years for women with infertility. Clomid stimulates the pituitary gland to cause stimulation of the ovaries. The result is the growth and development of a few eggs. During stimulation of the ovaries, at a certain point, the pituitary gland will trigger ovulation. In order to perform IVF, this signal from the pituitary gland must be blocked or at least controlled. Otherwise, many IVF cycles would be cancelled. A group of medications known as GnRH antagonists may be used to prevent ovulation.
A few small studies have been published using clomiphene citrate for in vitro fertilization. One study, published in 2003, evaluated 33 infertile couples who used clomid and compared them to 156 couples who had standard in vitro fertilization. The group that used clomiphene citrate ended up with fewer eggs, less embryos, less embryos transferred and less embryos that could be frozen. The pregnancy rate was less than one-half of the pregnancy rate of the standard in vitro fertilization group. This was due to a much lower implantation rate. In other words, the number of pregnancies produced per embryo transferred was much lower.
The authors suggested that the lower rate of implantation and pregnancy rate might have been due to adverse effects of the clomiphene citrate on the uterine lining rather then an effect of the embryos themselves.
Although each clomiphene citrate cycle was less expensive to perform, the couples would be predicted to spend more money overall because they would require a greater number of attempts to get the same number of pregnancies.
|Last Updated ( Friday, 26 October 2007 )|